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Human Radiotherapeutic Side Effect-Related Gene SNP Detection Kit

Human Radiotherapeutic Side Effect-Related Gene SNP Detection Kit

Next Generation Sequencing

CE-IVD Certificate no.No.MDD-SZ-XWA1-180523



Gene Detection and Radiotherapy


Radiotherapy is an effective treatment to control and kill tumor cells. However, this treatment can cause serious side effects, making patients suffering from great agonies and even influencing the treatment progress. There are huge differences in radiotherapeutic side effects for individuals. Therefore, the detection of radiotherapeutic side effect-related gene status before starting radiotherapy can predict and prevent the risk of side effects.


The individual difference in radiotherapeutic related side effects is associated with single nucleotide polymorphisms (SNP). By evaluating the SNP of related genes, patients would be able to receive effective and side-effect-minimized treatments, thus to maximize treatment efficacy and extend the survival time of the patients.


Example of Genotype and Radiotherapy


Studies have showed different risk levels of radiation-induced skin fibrosis after treatment of breast cancer patients with distinct DNMT1 genotypes. Patients with G allele may have a decreased risk of getting radiation-induced skin fibrosis compared to patients with AA/AG genotype.

 

GeneGenotypeCancer TypeRadiotherapy Related Side Effects
TGFB1GG/GA/AAproseate cancer

Patients with G allele may have an increased risk of getting

astrointestinal and genitourinary system related side effects.

AA/AG/GG

head and neck

cancer,

breast cancer

Patients with A allele may have an increased risk of radiodermatitis.
GSTP1AA/AG/GGbreast cancer

Patients with G allele may have an increased risk of radiation- induced 

skin fibrosis compared to patients with AA genotype.

HSPB1CC/CG/GGNSCLC

Patients with C allele may have an increased risk of

radiodermatitis compared to patients with GC/GG genotype.

NSCLC

Patients with C allele may have increased risk of ation esophagitis 

compared to patients with GC/GG genotype.

NSCLC

There are not direct association with Radiation pneumonitis and lung 

injury.


Detection Item


This kit detects 61 SNP loci in 42 genes related to radiothepeutic side effects, including:

XRCClTNFa,TXNRD2,ERCC2,TGFBl,VEGF,DNMTl,TP53,XRCC3,LIN28B,MTHFR,PONl,GSTPl,ATM,NOS2,APEXl,MLHl,

IL8,CD44,LIG4,ILlA,TNF,CYP2C8,IL4,NEILl,NBN,APC,NFKBIA,DEAD,Tpa,RAD51,NFE2L2,GSTAl,MGMT,TDG,GSK3β,

FSHR,MYO3B,TGFBR2,KDM3B,HSPBl and TXN.


The detection is based on next generation sequencing, with nucleic acid extracted from peripheral blood as template. The detection results can be used to predict the efficacy and side effects  of radiotherapy , thus, help the clinicians to select suitable treatments.



Performance Parameter


Product NameTechnologyProduct SpecificationMatched InstrumentSample Type

Human 

Radiotherapeutic

Side Effect-Related 

Gene SNP 

Detection Kit

RingCap?

16 tests/kit

or

32 tests/kit

Ion Torrent,

Illumina

peripheral

blood



Technical Highlights


Easy operation: With independent patented RingCap? technology, library construction can be donein two steps.


Rapid Detection: Only 2 working days from sample processing to reporting.


Comprehensive Detection: This kit can detect 61 loci in 42 targeted genes.Accurate and Reliable: Specific primer was used to capture targeted fragments.



Detection Process








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